所属部门：js4399金沙导航

　　职务/职称：副教授

　　荣誉：

　　电子邮件：guotiantian@nwu.edu.cn

　　个人简介

　　研究成果

　　期刊论文:

　　1. Guo, T. T.; Zhang, J. C.; Zhang, H.; Liu, Q. C.; Zhao, Y.; Hou, Y. F.; Bai, L.; Zhang, L.; Liu, X. Q.; Liu, X. Y.; Zhang, S. Y.; Bai, N. S*. Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. J. Asian. Nat. Prod. Res., 19, 793-802, 2017

　　2. Guo, T. T.; Wu, S. P.; Guo, S.; Bai, L.; Liu, Q. C. *; Bai, N. S*. Synthesis of a trisaccharide related to the cytotoxic triterpenoid saponins isolated from the bark of Albizia procera. Arch. Pharm., 348, 615-628, 2015. (SCI 四区)

　　3. Guo, T. T.; Liu, Q. C.; Zhang, L.; Wang, P.; Li, Y. X*. Facile synthesis of four natural triterpene saponins with important antitumor activity. Synthetic Commun. 41, 357-371, 2011. (SCI 四区)

　　4. Guo, T. T.; Liu, Q. C.; Wang, P.; Zhang, L.; Zhang, W.; Li, Y. X*. Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase. Carbohydr. Res. 344, 1167-1174, 2009. (SCI 三区)

　　5. Liu, Q. C.; Guo, T. T.; Li, D.; Li, F. H.; Li, W. H*. Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors. Eur. J. Med. Chem. 79, 34-46, 2014. (SCI 二区)

　　6. Liu, Q. C.; Guo, T. T.; Zhang, C.; Sun, J.; Li, W. H*. Synthesis of a trisaccharide related to the cytotoxic triterpenoid saponins isolated from the bark of Albizia procera. Helv. Chim. Acta, 97, 361-368, 2014. (SCI 四区)

　　7. Liu, Q. C.; Guo, T. T.; Zhang, L.; Yu, Y.; Wang, P.; Yang, J. F.; Li, Y. X*. Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors. Eur. J. Med. Chem., 63, 511-522, 2013. (SCI 二区)

　　8. Liu, Q. C*.; Guo, T. T.; Li, F. H.; Li, D. Concise synthesis of a new triterpenoid saponin from the roots of Gypsophila oldhamiana and its derivatives as a-glucosidase inhibitor. New J. Chem., 40, 9537-9549, 2016. (SCI 三区)

　　9. Liu, Q. C*.; Guo, T. T.; Li, D.; Li, W. H. Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea). Res. Chem. Intermed., 42, 1611-1626, 2016. (SCI 四区)

　　10. Liu, Q. C.; Guo, T. T.; Guo, S. D.; Li, W. H*.; Li, D. Synthesis and evaluation of four hederagenin glycosides as a-glucosidase inhibitor. Helv. Chim. Acta, 96 (1),142-149, 2013. (SCI 四区)

　　11. Liu, Q. C.; Guo, T. T.; Li, W. H*.; Li, D.; Feng, Z. L. Synthesis and evaluation of benzophenone O-glycosides as a-glucosidase inhibitors. Arch. Pharm., 345 (10), 771-783, 2012. (SCI 四区)

　　12. Guo, S.; Guo, T. T.; Cheng, N.; Liu, Q. C.; Zhang, Y. T.; Bai, L.; Zhang, L.; Cao, W.; Ho, C. T.; Bai, N. S.*. Hepatoprotective standardized EtOH-water extract from the seeds of Franxinus rhynchophylla Hance. J. Trad. Comp. Medicine DOI:10.1016/j.jtcme.2016.05.001, 2016. (SCI 四区)

　　13. Liu, Q. C.; Guo, T. T.; Guo, S. D.; Li, W. H*.; Li, D. Synthesis and evaluation of four hederagenin glycosides as a-glucosidase inhibitor. Helv. Chim. Acta, 96 (1),142-149, 2013. (SCI 四区)

　　14. Liu, Q. C.; Guo, T. T.; Li, W. H*.; Li, D.; Feng, Z. L. Synthesis and evaluation of benzophenone O-glycosides as a-glucosidase inhibitors. Arch. Pharm., 345 (10), 771-783, 2012. (SCI 四区)

　　15. Liu, Q. C.; Guo, T. T.; Fan, Z.; Li, D.; Li, W. H. First total synthesis of two new heterocyclic compounds: bretschneiderazines A and B. Chin. Chem. Lett., 22, 801-803, 2011. (SCI 四区)

　　16. Li, C. X.; Guo, T. T.; Wang, P.; Guan, H. S.; Li, Y. X. Semi-synthesis of several stigmasterol saponins. Chin. J. Chem., 24, 917-922, 2006. (SCI 四区)

　　17. Li, Y .X.; Zhang, Y. C.; Guo, T. T.; Guan, H. S.; Hao, Y.; Yu, B. Synthesis of the cytotoxic gitogenin 3β-O-[2-O-(α-L-rhamnopyranosyl)-β-D-galactopyranoside] and its congeners. Synthesis 5, 0775-0782, 2006. (SCI 三区)

　　18. Zhang, Y. C.; Li, Y. X.; Guo, T. T.; Guan, H. S.; Shi, J. W.; Yu, Q.; Yu, B. Synthesis of chlorogenin 6α-O-acyl-3-O-β-chacotrioside and their antitumor activities. Carbohydr. Res. 340, 1453-1459, 2005. (SCI 三区)

　　19. Liu, Q. C.; Li, W. H*.; Guo, T. T.; Li, D.; Fan, Z.; Yan, S. H. Efficient synthesis of a bis-glycosyl kaempferol from Fagonia taeckholmiana. Chem. Lett., 3, 324-325, 2011. (SCI 四区)

　　20. Liu, Q. C.; Wang, P.; Zhang, L.; Guo, T. T.; Lv, G. K.; Li, Y. X*. Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis. Carbohydr. Res. 344, 1276-1281, 2009. (SCI 三区)

　　21. Feng, Z. L.; Wu, S. P.; Li, W. H.; Guo, T. T.; Liu, Q. C*. Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea). Helv. Chim. Acta, 98, 1254-1266, 2015. (SCI 四区)

　　22. Liu, Q. C.; Liu, H. C.; Zhang, L.; Guo, T. T.; Wang, P.; Geng, M. Y.; Li, Y. X*. Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives. Eur. J. Med. Chem., 64, 1-15, 2013. (SCI 二区)

　　23. Liu, Q. C.; Fan, Z.; Li, D.; Li, W. H*.; Guo, T. T. Facile synthesis of several oleanane-type triterpenoid saponins. J. Carbohydr. Chem., 29, 386-402, 2011. (SCI 四区)

　　24. Guo, S.; Cui, X. Q.; Jiang, M.; Bai, L.; Tian, X.; Guo, T. T.; Liu, Q. C.; Zhang, L.; Ho, C. T.; Bai, N. S.*. Simultaneous characterization and quantification of 17 main compounds in Rabdosia rubescens by high performance liquid chromatography. J. Food Drug Anal. 25 (2), 417-424, 2017. (SCI 四区)

　　25. Bai, L.; Liu, Q. C.; Cen, Y. J.; Huang, J. P.; Zhang, X. X.; Guo, S.; Zhang, L.; Guo, T. T.; Ho, C. T.; Bai, N. S. A new sesquiterpene lactone glucoside and other constituents from Inula salsoloides with insecticidal activities on striped flea beetle (Phyllotreta striolata Fabricius). Nat. Prod. Res., Ahead of Print, 2017. (SCI 四区)

　　专利：

　　1.
刘克良，王晨宏，郭甜甜，含胺基小分子化合物的用途及制备生物降解材料的方法，2010.5.26，中国，200710002629.X。(授权)

　　2. 白乃生，刘庆超，张云婷，薛伟明，白璐，张丽，郭甜甜，温慧云，郭森，一种大叶白蜡树种子中降血糖物质裂环烯醚萜苷类化合物的提取制备方法，中国，CN
104758365。

　　3.
白乃生，刘庆超，白璐，张丽，郭甜甜，崔雪芹，吴勇，田潇，江咪，张鑫鑫，一种标准化红枣提取物及其制备和分析方法，中国，201410759326.2。

　　4.
白乃生，刘庆超，白璐，杨新文，张丽，郭甜甜，侯满伟，郭静，崔雪芹，一种标准化苹果提取物及其制备和分析方法，中国，201410759305.0。

　　5.
白乃生，刘庆超，张云婷，薛伟明，白璐，张丽，郭甜甜，温慧云，郭森，一种大叶白蜡树种子中降血糖物质裂环烯醚萜苷类化合物的提取制备技术，中国，20141075932
7.7。

　　6. 刘克良，王晨宏，郭甜甜，氨基酸在制备医药用生物降解材料中的用途及制备医药用生物降解材料的方法，中国，200710002631.7。

　　主持科研项目：

　　1.中国博士后科学基金第57批面上资助项目，以PTP1B为靶点的齐墩果酸糖苷的合成及构效关系研究，2015M572596，5万元，2015/06-2017/12，主持。

　　2. 陕西省社会发展科技攻关项目，2016SF-240，基于Bcl-2蛋白的大花旋覆花内酯糖苷抗肿瘤药物先导物的研究开发，5万元，在研，主持。

　　3. 陕西省教育厅自然科学基金，16JK1768, 基于Top1-Tdp1双重靶点的茚并异喹啉酮苯糖苷抑制剂的合成及抗肿瘤活性研究, 2万元，2016/06-2017/12，主持。

　　4、js4399金沙导航校内自然科学基金，14NW08，齐墩果酸三萜皂苷PTP1B抑制剂的设计合成及构效关系研究，2015/01-2016/12，2万元，主持。

　　获奖情况